Dense deposit disease in a child with febrile sore throat

Dense deposit disease in a child with febrile sore throat

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Dense deposit disease or membranoproliferative glomerulonephritis type II is a rare glomerulopathy characterized on renal biopsy by deposition of abnormal electron-dense material in the glomerular basement membrane.The pathophysiologic basis is uncontrolled systemic apple mtxn2ll/a activation of the alternate pathway of the complement cascade.C3 nephritic factor, an autoantibody directed against the C3 convertase of the alternate pathway, plays a key role.In some patients, complement gene mutations have gold ps5 controller skin been identified.

We report the case of a child who had persistent microscopic hematuria, proteinuria, and hypocomplementemia C3 for over 2 months.Renal biopsy confirmed the diagnosis of dense deposit disease.